Mitochondrial Renewal Kits, 60 Pks

The Center for Optimum Health Mitochondrial RenewalTM (MR) supplies three pharmacologically active, orally-bioavailable nutraceutical formulas intended for use in promoting mitochondrial biogenesis. The nutraceuticals found in the MR are safe and well-tolerated and have been uniquely prepared to enhance both absorption and residence time in the body so as to maximize patient benefit and satisfaction. All Center for Optimum Health formulas meet or exceed certified Good Manufacturing Process (cGMP) quality standards.

Mitochondrial biogenesis is the process by which new mitochondria are produced. Representing ~10% of body weight, mitochondria are cellular “fuel stations” responsible for supplying >95% of the body’s energy needs, among other roles.[1] Mitochondrial biogenesis can delay aging and the onset of age-associated disease.[2-4] This complex process involves more than 1,000 genes[2] and is responsible for producing 20% of total cellular protein.[1] Exercise and caloric restriction are two of the most powerful means of stimulating mitochondrial biogenesis,[2,3] most notably by activating the “master regulator” of mitochondrial biogenesis and function and metabolic fitness known as PGC-1α. PGC-1α is a transcriptional co-activator whose dysregulation has been implicated in aging and the pathogenesis of numerous age-associated diseases including but not limited to diabetes, obesity, sarcopenia and various neurological conditions.
PGC-1α-deficient animals display defects of energy metabolism, glucose disposal and insulin action, as well as reduced resistance to oxidative stress, increased fat mass, decreased muscle mass, impaired exercise perfor- mance and other problems suggestive of an impaired ability to adapt to metabolic and physiological stress.[5] Conversely, PGC-1α activation contributes to an increase in metabolic fitness in the form of an increased metabolic rate; improved glucose disposal, fatty acid oxidation and insulin function; increased resistance to oxidative stress, decreased fat mass and increased muscle mass and exercise performance.
In addition to being awarded several U.S. patents, the nutraceuticals found in the MR have been clinically tested for their oral bioavailability, safety and efficacy in activating PGC-1α and upstream cellular signaling cascades (see diagram on other side), thereby mimicking the powerful protective effects of exercise and caloric restriction on mitochondrial biogenesis, metabolic fitness, aging and the onset of age-associated diseases.

The Mitochondrial Renewal (MR), consisting of N.O.max ERTM, Mito SIRTTM and ALA CRTM contains pharmacologically-active, orally-bioavailable nutraceuticals that have been clinically tested for their safety and efficacy in stimulating key cellular signaling cascades involving Nitric Oxide (NO)(N.O.Max ER), SIRT1 (Mito SIRT) and AMPK (ALA CR), among others. These pathways ultimately lead to the activation of PGC-1α, the “master regulator” of mitochondrial biogenesis and function and metabolic fitness whose dysfunction has been associated with a number of age-associated diseases including but not limited to diabetes, obesity, sarcopenia and various neurological conditions.

PGC-1α-deficient animals display defects of energy metabolism, glucose disposal and insulin action, as well as reduced resistance to oxidative stress, increased fat mass, decreased muscle mass, impaired exercise perfor- mance and other problems suggestive of an impaired ability to adapt to metabolic and physiological stress.[5] Conversely, PGC-1α activation contributes to an increase in metabolic fitness in the form of an increased metabolic rate; improved glucose disposal, fatty acid oxidation and insulin function; increased resistance to oxidative stress, decreased fat mass and increased muscle mass and exercise performance.